After a brilliant outing in 2013 where they emerged African champions, played in the Confederations Cup and sealed a place at this summer's World Cup, Nigeria will be seeking to maintain their momentum when they face Mexico at the Georgia Dome in Atlanta.
Beside serving as a tool for team selection process, Stephen Keshis side will be gunning for their first win against El Tri,having been held to 2-2 draws in their last two meetings, in 2007 and 2013.
Mexico began their 2014 campaign on a bright note by hammering South Korea 4-0 in San Antonio on January 29 and, with just five games to go until they face Cameroon in the World Cup opener on June 13, Miguel Herrera's squad will be looking to impress again.
Keshi welcomes back captain Joseph Yobo to his team for the first time since the 2013 Africa Cup of Nations. He has also called up three new faces - former junior international Ramon Azeez, and Belgium-based strikers Imoh Ezekiel and Michael Uchebo.
With the Super Eagles bereft of Bright Dike, Nnamdi Oduamadi and Brown Ideye for this encounter, Ezekiel, Ejike Uzoenyi, and Uchebo have the chance to make a bold claim towards the World Cup squad.
The friendly will also give the Big Boss a chance to take a closer look at his reliable Europe-based players like Victor Moses, John Obi Mikel and perhaps Emmanuel Emenike, who only recently returned from injury.
Nigerias backline will have to watch out for Tigres forward Alan Pulido, who marked his international debut for Mexico with a hat trick last month against South Korea.