Manchester City may never have a better chance of overturning a two-goal deficit against Barcelona than at Camp Nou on Wednesday.After seeing Martin Demichelis sent off shortly before the hour mark, City slumped to a 2-0 defeat in the first leg of their last-16 tie with Barca at the Etihad Stadium last month.
While Lionel Messi opened the scoring from the penalty spot, having been fouled by Demichelis, it was Dani Alves who struck the hammer blow in stoppage time to hand City an almighty task to progress.
Barca have reached at least the final four of the competition in their last six attempts, lifting the trophy in 2009 and 2011.
Yet the Catalan giants head into Wednesday's game off the back of a surprise La Liga defeat to struggling Real Valladolid, which put a major dent in their domestic title ambitions.
The 1-0 loss at the Estadio Municipal Jose Zorrilla leaves Barca four points behind leaders Real Madrid ahead of the crucial Clasico towards the end of the month.
While Barca have been below their best since winning in Manchester, Manuel Pellegrini's men have endured mixed fortunes.
The Chilean picked up his first trophy as City boss with victory over Sunderland in the League Cup before his side crashed out of the FA Cup on Sunday at the hands of old foes Wigan Athletic.