Juventus and Inter will contest the 162nd Derby d'Italia in Turin on Sunday having endured contrasting fortunes in recent weeks.
The hosts sit six points clear of Roma at the top of Serie A and, despite being held to a 1-1 draw against Lazio last time out, are on course for a third straight Scudetto.
Inter, meanwhile, are 23 points off the title pace, having accrued just eight from their last nine games.
Antonio Conte's men had won 12 league games on the bounce before the Lazio result and they remain unbeaten at home in the Italian top flight since January last year.
Visiting sides have found trips to the Juventus Stadium tough, with the Bianconeri having conceded just six goals in 10 games, scoring 30 in the process.
Juve's attacking threat has been further improved by the addition of Southampton striker Pablo Daniel Osvaldo, who joined on loan from Southampton on Friday.
The Italy international scored 27 Serie A goals during his spell at Roma and bolsters a forward line that already features Carlos Tevez and Fernando Llorente.
Inter, often a title rival to Juventus in years gone by, have endured a tough start to the year, failing to win any of their five games in 2014, leaving them fifth in Serie A.
As well as crashing out of the Coppa Italia to Udinese, Walter Mazzarri's side have tasted defeat in league matches against Lazio and Genoa, while only managing home draws against Catania and Chievo.
Inter could hand a debut to recent arrivals Danilo D'Ambrosio and Hernanes, who have arrived from Torino and Lazio, respectively.
Captain Gianluigi Buffon is suspended for Juventus due to his dismissal against Lazio, while Inter midfielderEsteban Cambiasso is likely to miss clash due to a hamstring injury.
Juventus have won 76 of the sides' 161 meetings, with 40 games ending in draws - the most recent of which being a 1-1 stalemate at San Siro in September.
Inter took the lead on that occasion through Mauro Icardi after 73 minutes before Arturo Vidal equalised two minutes later.