Tim Sherwood takes charge of Tottenham for the first time as permanent manager when West Brom visit White Hart Lane on Boxing Day.
Sherwood was given a contract until the end of the 2014-15 season after guiding Spurs to victory against Southampton on Sunday in his first league game at the helm.
On Thursday, Tottenham will come up against a side with their own managerial issues in West Brom, who fired head coach Steve Clarke on December 14 following four straight Premier League defeats, with Keith Downing taking the reins for last Saturday's draw with Hull City.
Almost five years have passed since West Brom last beat Tottenham and the Midlands club have not won at White Hart Lane since 1984.
His decision to recall Emmanuel Adebayor, who fell out of favour under Villas-Boas, has already reaped rewards, with the striker scoring three goals in two matches. The Togolese was on target in a Capital One Cup quarter-final defeat to West Ham before grabbing a double against Southampton.
West Brom's last win came at the beginning of November when Crystal Palace were beaten 2-0 at the Hawthorns. Since then, the Baggies have drawn three and lost four but Downing is confident that his side, who sit three points clear of the relegation zone in 16th, can bounce back.
"[The players] were all back fit [on Monday] and raring to go heading into the Christmas period," he told reporters.
"We're expecting a difficult tie but certainly one where we can give them a few problems as well. They've got an open team so hopefully we can quell their strengths and attack their weaknesses."
Victor Anichebe is West Brom's only doubt, with a groin problem, although Downing expects the forward to be in contention for a place in his squad.
The hosts will be without Paulinho as he serves the final game of a three-match ban, while their injury list continues to grow.
Sandro (calf), Mousa Dembele (foot) and Aaron Lennon (abdomen) are all doubts, while Andros Townsend (hamstring), Younes Kaboul (thigh), Jan Vertonghen (ankle) and Harry Kane (back) are not expected to feature.